홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrogen Peroxide → 2-(3-fluoropropylamino)-4-[4-(quinolin-3-yl)-9H-carbazol-9-yl]benzamide

HRID 1877484
노트
인쇄 미리보기

반응식

HRID 1877484 반응식
F[C:2]1[CH:9]=[C:8]([N:10]2[C:22]3[CH:21]=[CH:20][CH:19]=[C:18]([C:23]4[CH:24]=[N:25][C:26]5[C:31]([CH:32]=4)=[CH:30][CH:29]=[CH:28][CH:27]=5)[C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-:34].[K+].[K+].Cl.[F:40][CH2:41][CH2:42][CH2:43][NH2:44].[OH-].[Na+].OO>CS(C)=O.C(O)C.C(N(CC)CC)C>[F:40][CH2:41][CH2:42][CH2:43][NH:44][C:2]1[CH:9]=[C:8]([N:10]2[C:22]3[CH:21]=[CH:20][CH:19]=[C:18]([C:23]4[CH:24]=[N:25][C:26]5[C:31]([CH:32]=4)=[CH:30][CH:29]=[CH:28][CH:27]=5)[C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:7]=[CH:6][C:3]=1[C:4]([NH2:5])=[O:34]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

9

반응물 5

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 219074553-Fluoropropan-1-amine hydrochlorideHCID 673078612-Fluoro-4-[4-(quinolin-3-yl)carbazol-9-yl]benzonitrile

생성물 1

HCID 583382502-(3-fluoropropylamino)-4-[4-(quinolin-3-yl)-9H-carbazol-9-yl]benzamide

시약·촉매·용매 3

HCID 679Dimethyl Sulfoxide용매HCID 702Ethanol용매HCID 8471Triethylamine용매

실험 절차

The process is carried out as in stage 3 of Example 3, but using 196.8 mg of 2-fluoro-4-[4-(quinolin-3-yl)-9H-carbazol-9-yl]benzonitrile, obtained according to stage 1 of Example 32, 197.3 mg of potassium carbonate, 1.081 g of 3-fluoropropylamine hydrochloride and 0.963 g of triethylamine in 2 ml of dimethyl sulphoxide. 0.904 ml of a 1M aqueous solution of sodium hydroxide, 0.875 ml of a 30% aqueous solution of hydrogen peroxide and 4 ml of ethanol are then added to the reaction medium. After treatment as in stage 3 of Example 3, and then purification by flash chromatography on silica gel, elution being carried out with a mixture of dichloromethane and ethanol (95/5 by volume), followed by crystallization from 1 ml of ethyl acetate, 185 mg of 2-(3-fluoropropylamino)-4-[4-(quinolin-3-yl)-9H-carbazol-9-yl]benzamide are thus obtained in the form of an off-white solid, the characteristics of which are the following:

후처리

  1. customobtained
  2. customAfter treatment as in stage 3 of Example 3, and then purification by flash chromatography
  3. washon silica gel, elution
  4. additionbeing carried out with a mixture of dichloromethane and ethanol (95/5 by volume)
  5. customfollowed by crystallization from 1 ml of ethyl acetate, 185 mg of 2-(3-fluoropropylamino)-4-[4-(quinolin-3-yl)-9H-carbazol-9-yl]benzamide
  6. customare thus obtained in the form of an off-white solid

출처 및 근거

ORD 기록
ord-d0e76e8c1a0c49dbb2ff06ba026512cd
출처 데이터셋
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08309721B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트