Methylhydrazine → 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

온도

-30 °C

At −30° C., difluoroacetyl fluoride (18.7 g, 0.187 mol; 98%) was introduced into a solution of methyl 3-piperidin-1-ylacrylate (99%, 29.05 g, 0.17 mol) and triethylamine (25.8 g, 0.255 mol) in toluene (250 ml). The reaction mixture was stirred at −30° C. for 3 h and then, over a period of 1 hour, warmed to room temperature. The reaction mixture was washed with deionized water (250 ml). After separation of the phases, the aqueous phase was extracted once with toluene (200 ml). The toluene phases were combined and, under reduced pressure, concentrated to about 350 ml. The reaction solution obtained in this manner was, at −50° C., added dropwise to a solution of methylhydrazine (8.78 g, 0.187 mol) in toluene (150 ml). The reaction mixture was stirred at −50° C. for 2 h and then, over a period of 1 hour, warmed to room temperature. Aqueous sodium hydroxide solution (10%, 105.3 g, 0.263 mol) was then added, and the reaction mixture was heated under reflux conditions for 2 h. After cooling to room temperature, the phases were separated. The toluene phase was extracted with aqueous sodium hydroxide solution (10% strength, 100 ml). The aqueous phases were combined, adjusted to a pH of 1 using hydrochloric acid (conc.) and cooled to 0° C. The precipitated solid was filtered off, washed with cyclohexane and dried at 60° C. under reduced pressure. This gave 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acid in an amount of 21.1 g (65% yield) in a purity of 91% (according to quant. HPLC). 1H-NMR (CDCl3): δ=3.85 (s, 2H), 3.95 (s, 3H), 7.12 (t, 1H), 7.9 ppm (s, 1H).

1. waitover a period of 1 hour
2. temperaturewarmed to room temperature
3. washThe reaction mixture was washed with deionized water (250 ml)
4. customAfter separation of the phases
5. extractionthe aqueous phase was extracted once with toluene (200 ml)
6. concentrationconcentrated to about 350 ml
7. customThe reaction solution obtained in this manner
8. customwas, at −50° C.
9. stirringThe reaction mixture was stirred at −50° C. for 2 h
10. waitover a period of 1 hour
11. temperaturewarmed to room temperature
12. temperaturethe reaction mixture was heated under reflux conditions for 2 h
13. temperatureAfter cooling to room temperature
14. customthe phases were separated
15. extractionThe toluene phase was extracted with aqueous sodium hydroxide solution (10% strength, 100 ml)
16. temperaturecooled to 0° C
17. filtrationThe precipitated solid was filtered off
18. washwashed with cyclohexane
19. customdried at 60° C. under reduced pressure

ORD 기록

ord-6fd7b186b3494a978af2ccd05532b376

출처 데이터셋

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08314233B2