Hydrochloric Acid → HCID 178468491, 화합물

HRID 1879922노트

반응식

HRID 1879922 반응식
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.[CH2:17]([O:19][C:20]([C:22]1([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)=[O:21])[CH3:18].Cl.CCN(C(C)C)C(C)C>C(O)C>[CH2:17]([O:19][C:20]([C:22]1([CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:23][CH2:24][N:25]([C:2]2[N:11]=[C:10]([OH:12])[C:9]3[C:4](=[CH:5][C:6]([O:15][CH3:16])=[C:7]([O:13][CH3:14])[CH:8]=3)[N:3]=2)[CH2:26][CH2:27]1)=[O:21])[CH3:18]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 53297794Ethyl 4-benzylpiperidine-4-carboxylateHCID 178486816HCID 178486816, 화합물

생성물 1

HCID 178468491HCID 178468491, 화합물수율 87%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1.2 g (5 mmol) 2-Chloro-6,7-dimethoxy-quinazolin-4-ol (commercially available), 2.26 g (8 mmol) 4-Benzyl-piperidine-4-carboxylic acid ethyl ester; hydrochloride and 1.93 g (15 mmol) DIPEA in 80 mL ethanol was heated to reflux for 62 h. The mixture was concentrated, the precipitate filtered off and washed with ethanol and diethyl ether. The residue was dried. 1.9 g (87%) of the title compound was isolated as white solid. MS (m/e): 452.2 (MH+).

후처리

  1. temperatureto reflux for 62 h
  2. concentrationThe mixture was concentrated
  3. filtrationthe precipitate filtered off
  4. washwashed with ethanol and diethyl ether
  5. customThe residue was dried

출처 및 근거

ORD 기록
ord-aa5c635bbc684f72bb11a0fa9105a0d8
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318749B2

반응 노트

불러오는 중…