Hydrochloric Acid → 2,2-Difluoro-2-phenylethanol
반응식
C([O:3][C:4](=O)[C:5]([F:13])([F:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)C.[BH4-].[Na+].Cl>C(O)C>[F:12][C:5]([F:13])([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[CH2:4][OH:3]참가 물질
5
실험 절차
To a solution of difluoro-phenyl-acetic acid ethyl ester (5.0 g, 25.0 mmol) in ethanol (150 mL) was added sodium borohydride (1.37 g, 36 mmol) at rt. The mixture was stirred for 2.5 h at room temperature. HCl aqueous (1N) was added and the resulting mixture was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and concentrated to obtain the product 2,2-difluoro-2-phenyl-ethanol (3.4 g, 86.1%), which was used to the next step without further purification.
후처리
- extractionthe resulting mixture was extracted with dichloromethane
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-364658702f8f4c9090de7765b4c86ee5
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318778B2
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