Water → 4,5-Dimethoxyphthalic acid

HRID 1881207

반응식

HRID 1881207 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[O:7][CH2:6]2.[OH-:15].[Na+].[O-][Mn](=O)(=O)=O.[K+].[OH2:23]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:6]([OH:23])=[O:15])[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8]([OH:7])=[O:14]

참가 물질

5

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 2304605,6-Dimethoxy-3H-isobenzofuran-1-oneHCID 516875Potassium Permanganate

생성물 1

HCID 2909884,5-Dimethoxyphthalic acid

실험 절차

To a mixture of 5,6-dimethoxy-3H-isobenzofuran-1-one (4.5 g) and 7% aqueous NaOH (47 ml) was added KMnO4 (4.0 g) diluted in water (125 ml). The mixture was stirred at room temperature for 4 days. Insoluble material was removed by filtration. The filtrate was cooled with ice-water bath and acidified with concentrated HCl. The acidic solution was extracted three times with ethyl acetate (300 ml). The combined organic layers were dried over anhydrous Na2SO4 and evaporated.

후처리

  1. customInsoluble material was removed by filtration
  2. temperatureThe filtrate was cooled with ice-water bath
  3. extractionThe acidic solution was extracted three times with ethyl acetate (300 ml)
  4. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-cb3ce5ebad0a4a1685bfee8cd89ad000
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318785B2

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