Hydrochloric Acid → 5-Bromo-6-(hydroxymethyl)nicotinaldehyde

HRID 1881731노트

반응식

HRID 1881731 반응식
C[O:2][CH:3](OC)[C:4]1[CH:5]=[C:6]([Br:12])[C:7]([CH2:10][OH:11])=[N:8][CH:9]=1.Cl.[OH-].[Na+]>C(Cl)Cl>[Br:12][C:6]1[CH:5]=[C:4]([CH:3]=[O:2])[CH:9]=[N:8][C:7]=1[CH2:10][OH:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67428521{5-[Bis(methyloxy)methyl]-3-bromo-2-pyridinyl}methanol

생성물 1

HCID 866648855-Bromo-6-(hydroxymethyl)nicotinaldehyde수율 87%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of {5-[bis(methyloxy)methyl]-3-bromo-2-pyridinyl}methanol (98 mg, 0.374 mmol) and 1N HCl (3.26 mL, 3.26 mmol) in DCM (5 mL) was stirred overnight. DCM and 1M NaOH solution were added. Extraction, drying (Na2SO4), and filtration afforded 5-bromo-6-(hydroxymethyl)-3-pyridinecarbaldehyde (70 mg, 87%) as a brown oil pure enough to be used in the next step.

후처리

  1. extractionExtraction
  2. customdrying
  3. filtration(Na2SO4), and filtration

출처 및 근거

ORD 기록
ord-d4a25755496243068795a2cba435d0c2
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318940B2

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