Hydrochloric Acid → 1-[2-(1,3-Dioxolan-2-yl)-1,3-thiazol-5-yl]ethane-1,2-diol
반응식
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[S:7][C:8]([C:11](=[O:17])[C:12](OCC)=[O:13])=[CH:9][N:10]=1.[BH4-].[Na+].Cl>C(O)C>[O:3]1[CH2:4][CH2:5][O:1][CH:2]1[C:6]1[S:7][C:8]([CH:11]([OH:17])[CH2:12][OH:13])=[CH:9][N:10]=1참가 물질
5
실험 절차
To a solution of ethyl [2-(1,3-dioxolan-2-yl)-1,3-thiazol-5-yl](oxo)acetate (2.00 g) in ethanol (20 mL) was slowly added sodium borohydride (0.50 g). The reaction mixture was stirred at room temperature for 1 hr, 6M hydrochloric acid was added, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated to give the title compound (1.50 g, yield 89%) as a colorless oil. MS: 218 (MH+).
후처리
- extractionthe mixture was extracted with ethyl acetate
- washThe ethyl acetate layer was washed with saturated brine
- dry with materialdried (MgSO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-ee859a4ebfa44a26ae315381f221b6ff
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318746B2
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