Hydrochloric Acid → 4-(Carboxymethoxy)benzoic acid

HRID 1882321노트

반응식

HRID 1882321 반응식
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]([O:14]C)=[O:13])=[CH:6][CH:5]=1.[OH-].[Na+].Cl>O>[C:12]([CH2:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:16])=[O:2])=[CH:5][CH:6]=1)([OH:14])=[O:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 887006methyl 4-(2-methoxy-2-oxoethoxy)benzoate

생성물 1

HCID 880244-(Carboxymethoxy)benzoic acid수율 91.4%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

4-Methoxycarbonylmethoxy-benzoic acid methyl ester 1 (50 grams, 223 mmol) was added to a solution of 2.5 M sodium hydroxide (250 mL) and heated to 80° C. for 5 hours. The reaction mixture was dilated with water (100 mL) and pH adjusted to 1 with concentrated HCl. Crude 76 was filtered, dried and given hot ethyl acetate slurry to give 76 (40 grams, 91.4%) as a white powder. M.p: >280° C.

후처리

  1. filtrationCrude 76 was filtered
  2. customdried

출처 및 근거

ORD 기록
ord-96efc83c26d34e4bb2acd342ac228817
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318973B2

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