Hydrochloric Acid → HCID 765906, 화합물

HRID 1882946노트

반응식

HRID 1882946 반응식
[C:1]([C:5]1[CH:23]=[CH:22][C:8]([C:9]([NH:11][C:12]2[CH:21]=[CH:20][CH:19]=[CH:18][C:13]=2[C:14]([O:16]C)=[O:15])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C1COCC1.[OH-].[Li+].Cl>CO>[C:1]([C:5]1[CH:23]=[CH:22][C:8]([C:9]([NH:11][C:12]2[CH:21]=[CH:20][CH:19]=[CH:18][C:13]=2[C:14]([OH:16])=[O:15])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 772645HCID 772645, 화합물

생성물 1

HCID 765906HCID 765906, 화합물수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A stirring solution of methyl 2-(4-tert-butylbenzoyl-amino)benzoate (10.4 g, 33.4 mmol) and THF (200 mL) was treated with 1 M aqueous lithium hydroxide (40 mL) and methanol (80 mL). After stirring over night at room temperature, the mixture was treated with 1 M aqueous HCl (40 mL) and the solvent was removed in vacuo. The residue was partitioned between ethyl acetate (400 mL) and brine (100 mL). The organic phase was separated, then dried with MgSO4, filtered and concentrated in vacuo to give 9.69 g (98%) of a white powder.

후처리

  1. customthe solvent was removed in vacuo
  2. customThe residue was partitioned between ethyl acetate (400 mL) and brine (100 mL)
  3. customThe organic phase was separated
  4. dry with materialdried with MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2602ed5e26304d29a755808754d1353c
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06759414B2

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