Water → HCID 178503532, 화합물

HRID 1885245노트

반응식

HRID 1885245 반응식
IC.[CH3:3][C:4]([C:7]1[CH:8]=[C:9]([CH:18]=[C:19]2[NH:23][C:22](=[S:24])[NH:21][C:20]2=[O:25])[CH:10]=[C:11]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:12]=1[OH:13])([CH3:6])[CH3:5].[CH:26](N(C(C)C)CC)(C)C.O>C(O)C>[CH3:17][C:14]([C:11]1[CH:10]=[C:9]([CH:18]=[C:19]2[NH:23][C:22]([S:24][CH3:26])=[N:21][C:20]2=[O:25])[CH:8]=[C:7]([C:4]([CH3:3])([CH3:5])[CH3:6])[C:12]=1[OH:13])([CH3:15])[CH3:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 81531DiisopropylethylamineHCID 541342535-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2-thioxo-4-imidazolidinone

생성물 1

HCID 178503532HCID 178503532, 화합물수율 100.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Iodomethane (0.5 mL, 8 mmols) is added to a stirred suspension of 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2-thioxo-4-imidazolidinone (2.5 g, 7.5 mmols) and diisopropylethylamine (1.35 mL, 7.7 mmols) in ethanol (25 mL), and the mixture is stirred under an inert atmosphere at room temperature. After 5 hours the resultant solution is stirred into water (150 ml). After a hour the precipitate is filtered off, rinsed three times with water and dried to afford the 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-1,5-dihydro-2-(methylthio)-4H-imidazol-4-one (2.6 g), mp 248°-249° C.

후처리

  1. filtrationAfter a hour the precipitate is filtered off
  2. washrinsed three times with water
  3. customdried

출처 및 근거

ORD 기록
ord-0c1b6d7c18324042810747cb4e934f1c
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05143928

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