Dimethyl Sulfide → 2-Methyl-1-phenyl-1-propanol

HRID 1885389

반응식

HRID 1885389 반응식
C[C@H](N)[C@H](O)C1C=CC=CC=1.Cl.COCCOCCOCCOC.CSC.C(SCC)C.ClC1C=C(Cl)C=CC=1/C=C(/N1C=NC=N1)\C(=O)C(C)(C)C.[CH:54]([C:57]([C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)=[O:58])([CH3:56])[CH3:55]>ClCCCl.ClC1C=CC=CC=1.CN(C)C=O>[C:59]1([CH:57]([OH:58])[CH:54]([CH3:55])[CH3:56])[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1

참가 물질

10

반응물 6

HCID 1068Dimethyl SulfideHCID 8189TriglymeHCID 9609Ethyl sulfideHCID 62943Phenylpropanolamine HydrochlorideHCID 69144IsobutyrophenoneHCID 11110117(E)-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-one

생성물 1

HCID 956262-Methyl-1-phenyl-1-propanol수율 97.2%

시약·촉매·용매 3

HCID 111,2-Dichloroethane용매HCID 6228Dimethylformamide용매HCID 7964Chlorobenzene용매

실험 절차

The same procedure as in Example 1 was repeated except that (+)-norephedrine hydrochloride was replaced by (-)-norephedrine hydrochloride, triglyme was replaced by 0.4 ml of dimethylformamide, dimethyl sulfide was replaced by diethyl sulfide, monochlorobenzene was replaced by 1,2-dichloroethane, (E)-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-one was replaced by 0.27 g (1.85 mmoles) of phenyl isopropyl ketone, and the reduction reaction was conducted for 18.5 hours, to obtain 0.27 g of crude (-)-phenylisobutyl alcohol.

후처리

  1. customthe reduction reaction

출처 및 근거

ORD 기록
ord-ac302dae37ed47baba21ba0f22a696a4
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05144039

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