Acetic Acid → 6-(4-Hydroxyphenyl)-2-naphthalenecarboxylic acid

HRID 1885777노트

반응식

HRID 1885777 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([OH:21])=[O:20])[CH:15]=3)[CH:10]=2)=[CH:5][CH:4]=1.C(O)(=O)C.C(OC(=O)C)(=O)C.Br>O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([OH:21])=[O:20])[CH:15]=3)[CH:10]=2)=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 7918Acetic AnhydrideHCID 150998986-(4-Methoxyphenyl)naphthalene-2-carboxylic acid

생성물 1

HCID 150998996-(4-Hydroxyphenyl)-2-naphthalenecarboxylic acid수율 82.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into a four-necked flask equipped with a stirring rod, dropping funnel, reflux condenser and thermometer was charged 0.63 g (0.0023 mol) of 2-(4'-methoxyphenyl)naphthalene-6-carboxylic acid of Example 9. To the compound were added 50 ml of acetic acid, 30 ml of acetic anhydride and 15 ml of 48% hydrobromic acid. The reaction was continued for 10 hours while the mixture was being heated with stirring, thereby obtaining clear solution. When 50 ml of water was added to the reaction solution, white precipitate was obtained. The precipitate was separated from the mixture by filtration, and then dried to obtain 0.5 g of 2-(4'-hydroxyphenyl)naphthalene-6-carboxylic acid. The yield of the product was 82 mol % on the basis of 2-(4'-methoxyphenyl)naphthalene-6-carboxylic acid used. The purity of the produce was 98%.

후처리

  1. customInto a four-necked flask equipped with a stirring rod
  2. temperaturereflux condenser
  3. temperaturewas being heated
  4. customobtaining clear solution
  5. customwhite precipitate was obtained
  6. customThe precipitate was separated from the mixture by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-6cec7d0a32ad4effbe52561894946a99
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05146025

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