Methyl iodide → 1H-benzimidazole, 1-methyl-2-(methylsulfonyl)-

HRID 1886042노트

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HRID 1886042 반응식
[CH3:1][S:2]([C:5]1[NH:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[N:6]=1)(=[O:4])=[O:3].[H-].[Na+].I[CH3:17]>CN(C=O)C>[CH3:1][S:2]([C:5]1[N:6]([CH3:17])[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1)(=[O:3])=[O:4]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 3035262-methanesulfonyl-1H-1,3-benzodiazole

생성물 1

HCID 6407151H-benzimidazole, 1-methyl-2-(methylsulfonyl)-수율 88.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
0 °C

실험 절차

To a cooled (0° C.), stirred solution of 2-(methylsulfonyl)-1H-benzimidazole (4.60 g, 0.023 mol) in DMF (25 mL) was added NaH (60% dispersion in mineral oil; 0.94 g, 0.023 mol) in several portions. After 1 hour, iodomethane (3.33 g, 0.023 mol) was added. The cooling bath was removed and stirring was continued for 18 hours. The mixture was recooled to 0° C., H2O (75 mL) was added, and the off-white precipitate was collected by filtration to give 4.30 g (88%) of product m.p. 131°-132° C.

후처리

  1. customThe cooling bath was removed
  2. waitwas continued for 18 hours
  3. customwas recooled to 0° C.
  4. additionH2O (75 mL) was added
  5. filtrationthe off-white precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-0331452ae5cb4b1683b71b525695cc46
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05149700

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