Donepezil → Donepezil methanesulfonate

HRID 1888018

반응식

HRID 1888018 반응식
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH2:19][CH:18]([CH2:20][CH:21]3[CH2:26][CH2:25][N:24]([CH2:27][C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH2:23][CH2:22]3)[C:16](=[O:17])[C:11]2=[CH:12][C:13]=1[O:14][CH3:15].C(OCCC)CC>C(O)C>[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH2:19][CH:18]([CH2:20][CH:21]3[CH2:22][CH2:23][N:24]([CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:25][CH2:26]3)[C:16](=[O:17])[C:11]2=[CH:12][C:13]=1[O:14][CH3:15].[S:2]([O-:5])(=[O:4])(=[O:3])[CH3:1]

참가 물질

5

반응물 3

HCID 3152DonepezilHCID 6395Methanesulfonic AcidHCID 8114Propyl ether

생성물 1

HCID 131730793Donepezil methanesulfonate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Methanesulfonic acid (1.3 ml, dissolved in 11 ml of absolute ethanol) is slowly added to a solution of Donepezil (3.79 g) in absolute ethanol (38 ml) with stirring at room temperature, and 50 ml of dipropyl ether is added. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 180.3° C.

후처리

  1. customThe solid precipitated
  2. filtrationis filtered
  3. customdried at 55° C. under vacuum

출처 및 근거

ORD 기록
ord-2dc43549994e4f18bcf31875780ac882
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501779B2

연결된 노트

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