Donepezil → Donepezil Maleate

HRID 1888064

반응식

HRID 1888064 반응식
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[CH3:9][O:10][C:11]1[CH:12]=[C:13]2[CH2:22][CH:21]([CH2:23][CH:24]3[CH2:29][CH2:28][N:27]([CH2:30][C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:26][CH2:25]3)[C:19](=[O:20])[C:14]2=[CH:15][C:16]=1[O:17][CH3:18].C(OCCC)CC>C(OCC)(=O)C>[CH3:9][O:10][C:11]1[CH:12]=[C:13]2[CH2:22][CH:21]([CH2:23][CH:24]3[CH2:25][CH2:26][N:27]([CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[CH2:28][CH2:29]3)[C:19](=[O:20])[C:14]2=[CH:15][C:16]=1[O:17][CH3:18].[C:1]([O-:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([O-:6])=[O:5]

참가 물질

5

반응물 3

HCID 3152DonepezilHCID 8114Propyl etherHCID 444266Maleic Acid

생성물 1

HCID 24801486Donepezil Maleate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Maleic acid (1.161 g, dissolved in 10 ml of 2-propanol) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (20 ml) with stirring at room temperature followed by adding 10 ml of dipropyl ether. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 126.8° C.

후처리

  1. customThe solid precipitated
  2. filtrationis filtered
  3. customdried at 55° C. under vacuum

출처 및 근거

ORD 기록
ord-32da11b15fde4c9cb03ca14a19bc2d79
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501779B2

연결된 노트

불러오는 중…