1-Hydroxybenzotriazole → HCID 46926698, 화합물

HRID 1891107노트

반응식

HRID 1891107 반응식
[CH3:1][N:2]1[C:7]2=[CH:8][S:9][C:10](C)=[C:6]2[C:5](=[O:12])[N:4]([CH3:13])[C:3]1=[O:14].[Cl:15][C:16]1[CH:17]=[C:18]([C:23]2[N:24]=[C:25]([NH2:28])[S:26][CH:27]=2)[CH:19]=[CH:20][C:21]=1[Cl:22].CCN=C=NC[CH2:35][CH2:36]N(C)C.Cl.C1C=CC2N([OH:50])N=NC=2C=1>CN(C1C=CN=CC=1)C.ClCCCl>[Cl:15][C:16]1[CH:17]=[C:18]([C:23]2[N:24]=[C:25]([NH:28][C:35](=[O:50])[CH2:36][C:7]3[C:6]4[C:5](=[O:12])[N:4]([CH3:13])[C:3](=[O:14])[N:2]([CH3:1])[C:10]=4[S:9][CH:8]=3)[S:26][CH:27]=2)[CH:19]=[CH:20][C:21]=1[Cl:22]

참가 물질

7

반응물 4

HCID 757711-HydroxybenzotriazoleHCID 6185364-(3,4-Dichlorophenyl)-1,3-thiazol-2-amineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 710080931,3,5-trimethylthieno[3,4-d]pyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 46926698HCID 46926698, 화합물

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 111,2-Dichloroethane용매

실험 절차

The title compound was prepared according to the general procedure (Method A) by coupling Intermediate 1 (100 mg, 0.393 mmol) with 4-(3,4-dichlorophenyl)-1,3-thiazol-2-amine (96.5 mg, 0.393 mmol) in the presence of EDCI hydrochloride (90 mg, 0.471 mmol), HOBt (16 mg, 0.118 mmol) and DMAP (5 mg, 0.039 mmol) in 1,2 dichloroethane (4 ml) to give 40 mg of the product as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 3.19 (s, 3H), 3.47 (s, 3H), 4.06 (s, 2H), 7.07 (s, 1H), 7.70 (d, J=8.4 Hz, 1H), 7.80 (s, 1H), 7.89 (d, J=6.9 Hz, 1H), 8.14 (s, 1H), 12.43 (br s, 1H); APCI-MS (m/z) 479.32 (M−H)+.

출처 및 근거

ORD 기록
ord-a2f6d611188e43ec83b2b2a8361b7864
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507503B2

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