1-Hydroxybenzotriazole → 1246761-03-4

HRID 1891108노트

반응식

HRID 1891108 반응식
[CH3:1][N:2]1[C:7]2=[CH:8][S:9][C:10](C)=[C:6]2[C:5](=[O:12])[N:4]([CH3:13])[C:3]1=[O:14].[F:15][C:16]1[C:21]([C:22]([F:25])([F:24])[F:23])=[C:20]([F:26])[CH:19]=[CH:18][C:17]=1[C:27]1[N:28]=[C:29]([NH2:32])[S:30][CH:31]=1.CCN=C=NC[CH2:39][CH2:40]N(C)C.Cl.C1C=CC2N([OH:54])N=NC=2C=1>CN(C1C=CN=CC=1)C.ClCCCl>[F:15][C:16]1[C:21]([C:22]([F:23])([F:24])[F:25])=[C:20]([F:26])[CH:19]=[CH:18][C:17]=1[C:27]1[N:28]=[C:29]([NH:32][C:39](=[O:54])[CH2:40][C:7]2[C:6]3[C:5](=[O:12])[N:4]([CH3:13])[C:3](=[O:14])[N:2]([CH3:1])[C:10]=3[S:9][CH:8]=2)[S:30][CH:31]=1

참가 물질

7

반응물 4

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 574616514-[2,4-Difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amineHCID 710080931,3,5-trimethylthieno[3,4-d]pyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 469266991246761-03-4

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 111,2-Dichloroethane용매

실험 절차

The title compound was prepared according to the general procedure (Method A) by coupling Intermediate 1 (100 mg, 0.393 mmol) with 4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine (110 mg, 0.393 mmol) in the presence of EDCI hydrochloride (90 mg, 0.471 mmol), HOBt (16 mg, 0.117 mmol) and DMAP (5 mg, 0.039 mmol) in 1,2 dichloroethane (4 ml) to give 20 mg of the product as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 3.19 (s, 3H), 3.47 (s, 3H), 4.07 (s, 2H), 7.08 (s, 1H), 7.55 (t, J=9.0 Hz, 1H), 7.62 (s, 1H), 8.34 (q, J=6.9 Hz, 1H), 12.50 (br s, 1H); ESI-MS (m/z) 517.09 (M+H)+.

출처 및 근거

ORD 기록
ord-b5c82640df7042a0a952d3baa315f011
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507503B2

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