Hydrochloric Acid → (3-Ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid

HRID 1892043

반응식

HRID 1892043 반응식
C[O:2][C:3](=[O:24])[CH:4]([S:22][CH3:23])[O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][C:10]([C:16]#[C:17][Si](C)(C)C)=[CH:9]2.[OH-].[Na+].Cl>C(O)C.O>[C:16]([C:10]1[CH:11]=[N:12][C:13]2[C:8]([CH:9]=1)=[CH:7][C:6]([O:5][CH:4]([S:22][CH3:23])[C:3]([OH:24])=[O:2])=[CH:15][CH:14]=2)#[CH:17]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66717765Methylsulfanyl-(3-trimethylsilanylethynyl-quinolin-6-yloxy)-acetic acid methyl ester

생성물 1

HCID 59565474(3-Ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid수율 92.9%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

To a solution of methylsulfanyl-(3-trimethylsilanylethynyl-quinolin-6-yloxy)-acetic acid methyl ester (5 g) from Step 1, in ethanol (50 ml), a 2M solution of sodium hydroxide in water (9.74 ml) was added. The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into ice-cold water (200 ml) and acidified with a 2 M solution of hydrochloric acid in water (9.74 ml). The precipitate was filtered off and washed with water to give (3-ethynyl-quinolin-6-yloxy)-methylsulfanyl-acetic acid as yellowish solid (3.53 g).

후처리

  1. filtrationThe precipitate was filtered off
  2. washwashed with water

출처 및 근거

ORD 기록
ord-86a82cad36de4f51ac2ed7f1c0719059
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507509B2

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