1-Bromooctane → N1,N1,N5,N5-tetraoctylnaphthalene-1,5-diamine

HRID 1897379

반응식

HRID 1897379 반응식
[C:1]1([NH2:12])[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][CH:2]=1.Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].C(=O)([O-])[O-].[K+].[K+]>C(O)CCC.[I-].[K+]>[CH2:14]([N:12]([CH2:9][CH2:10][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[C:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([N:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[C:5]=2[CH:4]=[CH:3][CH:2]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

참가 물질

6

반응물 3

HCID 81401-BromooctaneHCID 11430Potassium CarbonateHCID 167201,5-Diaminonaphthalene

생성물 1

HCID 68441382N1,N1,N5,N5-tetraoctylnaphthalene-1,5-diamine수율 38.3%

시약·촉매·용매 2

HCID 4875Potassium Iodide촉매HCID 2631-Butanol용매

반응 조건

온도
110 °C

실험 절차

Naphthalene-1,5-diamine (3.14 g, 19.8 mmol), 1-bromooctane (25.25 g, 0.130 mol), potassium carbonate (11.79 g, 85.3 mmol), and potassium iodide (0.05 g, 0.30 mmol) was stirred in dry butanol (150 ml) and heated to 110° C. for 36 h. The reaction was quenched with water and extracted with ether three times. The combined organic phase was washed three times with water and evaporated to give black oil which was distilled under reduced pressure at 90° C. to yield a black tar. This was purified with flash chromatography using hexane as mobile phase to obtain colourless oil which crystallised to yield N1,N1,N5,N5-tetraoctylnaphthalene-1,5-diamine (2.3 g, 3.79 mmol) as white crystals. 1H-NMR (CDCl3, δ): 0.85 (t, 12H), 1.0-1.4 (m, 40H), 1.4-1.6 (m, 8H), 3.08 (t, 8H), 7.1 (d, 2H), 7.35 (t, 2H), 8.01 (d, 2H) MS MALDI-TOF (m/z): 606.574

후처리

  1. customThe reaction was quenched with water
  2. extractionextracted with ether three times
  3. washThe combined organic phase was washed three times with water
  4. customevaporated
  5. customto give black oil which
  6. distillationwas distilled under reduced pressure at 90° C.
  7. customto yield a black tar
  8. customThis was purified with flash chromatography
  9. customto obtain colourless oil which
  10. customcrystallised

출처 및 근거

ORD 기록
ord-cc4cbe8c62b2426983183ff61b6f89b8
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08519037B2

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