Sodium Hydroxide → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid

HRID 1898938

반응식

HRID 1898938 반응식
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([O:16]CC)=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C.O>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([OH:16])=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 15468682Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate

생성물 1

HCID 109442901-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid수율 88.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 1.55 g of ethyl 1-isopropyl-2(1H)-quinolone-3-carboxylate and 0.28 g of sodium hydroxide in a mixture of 10 ml of ethanol and 2 ml of water was stirred overnight at room temperature. After the solvent was distilled off, dil. hydrochloric acid was added to the residue. The precipitated solid was taken by filtration, washed with water and dried to give 1.22 g of 1-isopropyl-2(1H)-quinolone-3-carboxylic acid.

후처리

  1. distillationAfter the solvent was distilled off
  2. additiondil. hydrochloric acid was added to the residue
  3. filtrationThe precipitated solid was taken by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-517c823989d348d195c3c138d15bd565
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05571820

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