Methyl iodide → 2-Chloro-1-methoxy-3-methyl-4-nitrobenzene

HRID 1898991노트

반응식

HRID 1898991 반응식
[Cl:1][C:2]1[C:7]([CH3:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[OH:12].[H-].[Na+].[CH3:15]I>CN(C=O)C>[Cl:1][C:2]1[C:7]([CH3:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[O:12][CH3:15]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 131473552-Chloro-3-methyl-4-nitrophenol

생성물 1

HCID 137023832-Chloro-1-methoxy-3-methyl-4-nitrobenzene수율 81.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-Chloro-3-methyl-4-nitrophenol (9.39 g, 50.0 mmol) was reacted with sodium hydride (50%, 2.64 g, 55.0 mmol) and methyl iodide (7.81 g, 55.0 mmol) in dry DMF (200 ml) by the method described in 1 (a). After treatment with water, the product was extracted with chloroform, and the dried extract evaporated to dryness, leaving an oil which crystallised on cooling, leaving solid 2-chloro-3-methyl-4-nitroanisole (8.19 g).

후처리

  1. extractionAfter treatment with water, the product was extracted with chloroform
  2. extractionthe dried extract
  3. customevaporated to dryness
  4. customleaving an oil which
  5. customcrystallised
  6. temperatureon cooling

출처 및 근거

ORD 기록
ord-7a595a9bb28245488bfb0cabff633f57
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05571833

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