2,4-Difluoroaniline → 2-bromo-N-(2,4-difluorophenyl)acetamide

HRID 1899393노트

반응식

HRID 1899393 반응식
[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[Br:10][CH2:11][C:12](Cl)=[O:13].CCN(C(C)C)C(C)C>ClCCl>[Br:10][CH2:11][C:12]([NH:4][C:3]1[CH:5]=[CH:6][C:7]([F:9])=[CH:8][C:2]=1[F:1])=[O:13]

참가 물질

5

반응물 3

HCID 97092,4-DifluoroanilineHCID 81531DiisopropylethylamineHCID 89602Bromoacetyl chloride

생성물 1

HCID 34164012-bromo-N-(2,4-difluorophenyl)acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5.16 g (40 mmol) of 2,4-difluoroaniline and 6.3 g (40 mmol) of bromoacetyl chloride are treated in 200 ml of dichloromethane with 5.17 g (40 mmol) of Hunig base. After 4 h, the mixture is washed twice with 1N hydrochloric acid and once with water, dried (MgSO4) and concentrated.

후처리

  1. washthe mixture is washed twice with 1N hydrochloric acid and once with water
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d4b3cbeaf5614edda9a0e9989ab48ab0
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05571921

반응 노트

불러오는 중…