tert-Butanol → 1-cyclopropyl-8-(1-Bocamino-1-cyclopropyl)-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester

HRID 1900

반응식

HRID 1900 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:15](=[O:16])[N:14]2[C:9]([C:10]([CH3:24])=[C:11]([C:18]3(C(O)=O)[CH2:20][CH2:19]3)[C:12]([F:17])=[CH:13]2)=[C:8]([CH:25]2[CH2:27][CH2:26]2)[CH:7]=1)=[O:5])[CH3:2].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:35])C=CC=CC=1.[C:45]([OH:49])([CH3:48])([CH3:47])[CH3:46].C([N:52]([CH2:55]C)CC)C>O1CCOCC1>[CH2:1]([O:3][C:4]([C:6]1[C:15](=[O:16])[N:14]2[C:9]([C:10]([CH3:24])=[C:11]([C:18]3([NH:52][C:55]([O:49][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:35])[CH2:19][CH2:20]3)[C:12]([F:17])=[CH:13]2)=[C:8]([CH:25]2[CH2:26][CH2:27]2)[CH:7]=1)=[O:5])[CH3:2]

참가 물질

6

반응물 4

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 571289751-cyclopropyl-8-(1-hydroxycarbonyl-1-cyclopropyl)-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester

생성물 1

HCID 571023201-cyclopropyl-8-(1-Bocamino-1-cyclopropyl)-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A sample of the product from Step 477d is heated with diphenylphosphoryl azide, t-butanol, triethylamine and dioxane. The solvents is removed under vacuum. The residue is dissolved in methylene chloride, washed with water and dried over MgSO4 and concentrated under vacuum. The title compound is purified by chromatography on silica gel.

후처리

  1. customThe solvents is removed under vacuum
  2. dissolutionThe residue is dissolved in methylene chloride
  3. washwashed with water
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated under vacuum
  6. customThe title compound is purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-e9a35b5778f84e018ef46a7daf51dbfd
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726182

연결된 노트

불러오는 중…