Diiodomethane → Bicifadine
반응식
[C:1]1([CH3:12])[CH:6]=[CH:5][C:4]([C:7]2[CH2:8][NH:9][CH2:10][CH:11]=2)=[CH:3][CH:2]=1.[CH2:13](I)I>C1C=CC=CC=1.[Cu]>[C:1]1([CH3:12])[CH:2]=[CH:3][C:4]([C:7]23[CH2:13][CH:11]2[CH2:10][NH:9][CH2:8]3)=[CH:5][CH:6]=1참가 물질
5
실험 절차
A mixture of 3-(p-tolyl)-3-pyrroline, methylene iodide, and powdered copper in a molar ration of 1:2:4 is heated in benzene for about 50 hours. Filtration and evaporation of the solution gives 1-(p-tolyl)-3-azabicyclo[3.1.0]hexane.
후처리
- filtrationFiltration and evaporation of the solution
출처 및 근거
- ORD 기록
- ord-67f402ae0a6640d2b0a6e50f5d17463b
- 출처 데이터셋
- uspto-grants-1984_03
- 특허 번호
- US04435419
반응 노트
불러오는 중…