Thionyl Chloride → 2-(1-Chloroethyl)-1,3-difluorobenzene

HRID 1903831

반응식

HRID 1903831 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[CH:4](O)[CH3:5].S(Cl)([Cl:14])=O>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[CH:4]([Cl:14])[CH3:5]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 50120752,6-Difluoro-alpha-methylbenzyl alcohol2회

생성물 1

HCID 5880552-(1-Chloroethyl)-1,3-difluorobenzene수율 99.8%

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
60 °C

실험 절차

2,6-Difluoro-alpha-methylbenzyl alcohol of (B) (14.9 g, 0.094 mol) is dissolved in chloroform (50 ml) and warmed to 60° C. Thionyl chloride (22.4 g, 0.19 mol) is now added dropwise. The whole is kept at 60° C. for 4 hours then stirred overnight at room temperature. Excess thionyl chloride and chloroform are then removed on a rotary evaporator, resulting in pure title product (16.6 g, 99.8%).

후처리

  1. customExcess thionyl chloride and chloroform are then removed on a rotary evaporator

출처 및 근거

ORD 기록
ord-05eb1a4e6dd5472fb76ab7ef7c7bbbc6
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04438271

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