Hydrochloric Acid → HCID 13729408, 화합물

HRID 1906433

반응식

HRID 1906433 반응식
[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[NH2:2].[ClH:18]>C(Cl)(Cl)Cl>[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][Cl:18])=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[NH2:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 137294032-Carbamoyl-7-(2,3-epoxypropoxy)benzofuran

생성물 1

HCID 13729408HCID 13729408, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

There was suspended 2.3 g of 2-carbamoyl-7-(2,3-epoxypropoxy)benzofuran obtained in Reference Example 1 in 70 ml of chloroform, and thereto 15 ml of concentrated hydrochloric acid was added. Thereafter, the mixture was vigorously stirred at room temperature for 15 minutes. After the chloroform layer was washed with water and dried with magnesium sulfate, the solvent was distilled away from the reaction mixture under reduced pressure. The resultant residue was purified by silica-gel chromatography (eluent: 2 % ethanol-chloroform) to give the desired compound.

후처리

  1. washAfter the chloroform layer was washed with water
  2. dry with materialdried with magnesium sulfate
  3. distillationthe solvent was distilled away from the reaction mixture under reduced pressure
  4. customThe resultant residue was purified by silica-gel chromatography (eluent: 2 % ethanol-chloroform)

출처 및 근거

ORD 기록
ord-00a4f93f0c5e423b940f80ea6c6f94fd
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04652566

연결된 노트

불러오는 중…