Hydrochloric Acid → 2-Iodo-5-(trifluoromethyl)phenol
반응식
[H-].[Na+].[F:3][C:4]([F:13])([F:12])[C:5]1[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=1.[I:14]I.Cl>CCCCCC.C1(C)C=CC=CC=1.CCOCC>[I:14][C:8]1[CH:9]=[CH:10][C:5]([C:4]([F:12])([F:13])[F:3])=[CH:6][C:7]=1[OH:11]참가 물질
8
실험 절차
To a round bottom flask under N2 was added 14.2 g (0.296 mole) of sodium hydride, 50% in oil. The NaH was washed twice with hexane, and 33.15 g (0.205 mole) of m-trifluoromethylphenol in 1 liter of toluene was added. After five minutes 51.9 g (0.205 mole) of iodine was added all at once, and the solution allowed to stir overnight. The reaction was poured into 3N HCl, ether added, and the separated organic layer washed with water, brine and dried with MgSo4. The solvent was evaporated in vacuo to give 60.3 g (100% yield) of 2-iodo-5-trifluoromethylphenol, mp 36°-38° C.
후처리
- additionwas added
- additionadded
- washthe separated organic layer washed with water, brine
- customdried with MgSo4
- customThe solvent was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-eb70b5ed65b748b3924dafad5bc5ddaf
- 출처 데이터셋
- uspto-grants-1987_03
- 특허 번호
- US04652584
반응 노트
불러오는 중…
