Hydrochloric Acid → 4-Amino-5-nitropicolinic acid
반응식
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][N:5]=1.[OH-].[Na+].Cl>CO>[NH2:10][C:8]1[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][N:5]=[C:4]([C:3]([OH:14])=[O:2])[CH:9]=1참가 물질
5
실험 절차
A mixture of methyl-4-amino-5-nitropicolinate (200 mg, 1.01 mmol) and NaOH (aq, 1M, 2.0 mL, 2.0 mmol) in methanol was stirred at ambient temperature for 10 min. The mixture was acidified by addition of HCl (aq, 1M, 2.1 mL, 2.1 mmol) and concentrated i. vac. and the aqueous residing mixture filtered. The solid was washed with water and dried i. vac.
후처리
- concentrationconcentrated i
- filtrationand the aqueous residing mixture filtered
- washThe solid was washed with water
- customdried i
출처 및 근거
- ORD 기록
- ord-55befc6ebcd748beac40249d533ed487
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08598190B2
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