2-Amino-1-(4-fluorophenyl)ethanone → 2-Amino-1-(4-fluorophenyl)ethan-1-ol

HRID 1908256

반응식

HRID 1908256 반응식
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)[OH:4]

참가 물질

4

반응물 2

HCID 15811772-Amino-1-(4-fluorophenyl)ethanoneHCID 4311764Sodium borohydride

생성물 1

HCID 98272-Amino-1-(4-fluorophenyl)ethan-1-ol수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution consisting of 2-amino-1-(4-fluoro-phenyl)-ethanone (150 mg, 0.9 mmol) and MeOH (5 mL) was added NaBH4 (97 mg, 2.6 mmol). The mixture was stirred at rt for 45 min and then concentrated to dryness. The residue was diluted with EtOAc and washed with a satd. NH4Cl solution before drying (Na2SO4), and concentrating to give 2-amino-1-(4-fluoro-phenyl)-ethanol (139 mg, 100%) which was used without further purification.

후처리

  1. concentrationconcentrated to dryness
  2. additionThe residue was diluted with EtOAc
  3. washwashed with a satd
  4. dry with materialNH4Cl solution before drying (Na2SO4)
  5. concentrationconcentrating

출처 및 근거

ORD 기록
ord-3de15211aafd4142a970ccbc6622e103
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598202B2

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