Hydrochloric Acid → 2-chloro-6-methylthieno[3,2-d]pyrimidin-4(3H)-one

HRID 1910452노트

반응식

HRID 1910452 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][C:9]([CH3:11])=[CH:8][C:6]=2[N:7]=1.[OH-:13].[Na+].Cl>C1COCC1>[Cl:1][C:2]1[NH:3][C:4](=[O:13])[C:5]2[S:10][C:9]([CH3:11])=[CH:8][C:6]=2[N:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 127242682,4-Dichloro-6-methylthieno[3,2-d]pyrimidine

생성물 1

HCID 1363597872-chloro-6-methylthieno[3,2-d]pyrimidin-4(3H)-one수율 92%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 2,4-dichloro-6-methylthieno[3,2-d]pyrimidine (450 mg, 2.05 mmol), aqueous NaOH (1N, 4 mL) and THF (4 mL) was stirred at room temperature under N2. The reaction was monitored by HPLC until the reaction was completed. Then the mixture was neutralized to PH 5 by addition of 2N aqueous HCl. The solid was filtrated and dried to give 380 mg of 2-chloro-6-methylthieno[3,2-d]pyrimidin-4(3H)-one (yield was 92%) as a yellow solid. MS obsd. (ESI+) [(M+H)+]: 201.

후처리

  1. filtrationThe solid was filtrated
  2. customdried

출처 및 근거

ORD 기록
ord-f1444c152b824f1bae8381be8ed4024a
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604019B2

반응 노트

불러오는 중…