Water → HCID 57406041, 화합물
반응식
[C:1](#[N:7])[CH2:2][CH2:3][CH2:4][C:5]#[N:6].N[NH:9][C:10]([NH2:12])=[S:11].O.[OH-].[Na+]>C(O)(C(F)(F)F)=O>[CH2:2]([C:1]1[S:11][C:10]([NH2:12])=[N:9][N:7]=1)[CH2:3][CH2:4][C:5]1[S:11][C:10]([NH2:12])=[N:9][N:6]=1참가 물질
6
반응 조건
- 온도
- 85 °C
실험 절차
A mixture of glutaronitrile (5.00 g, 53.13 mmol) and thiosemicarbazide (9.68 g, 106.26 mmol) in TFA (50 mL) was heated at 85° C. for 4 h. The reaction was cooled to room temperature and poured into a mixture of ice and water. Sodium hydroxide pellets were added to the mixture until it was basic (pH 14). The white precipitate was collected by suction filtration, rinsed with water and dried to provide 5,5′-(propane-1,3-diyl)-bis(1,3,4-thiadiazol-2-amine) (1004, 13.72 g). 1H NMR (300 MHz, DMSO-d6) δ 7.06-7.03 (s, 4H), 2.87 (t, J=7.5 Hz, 4H), 2.02-1.95 (m, 2H).
후처리
- temperatureThe reaction was cooled to room temperature
- filtrationThe white precipitate was collected by suction filtration
- washrinsed with water
- customdried
출처 및 근거
- ORD 기록
- ord-8911f32819d14727a87facc77d5c305c
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08604016B2
반응 노트
불러오는 중…