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Hydrochloric Acid → 3-(Dimethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-one hydrochloride

HRID 1915198
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HRID 1915198 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=1)=[O:3].[ClH:14].[CH3:15][NH:16][CH3:17].[CH2:18]=O.Cl>C(O)C>[ClH:14].[CH3:15][N:16]([CH3:18])[CH2:17][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[CH:5]=1)=[O:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 676823'-(Trifluoromethyl)acetophenone

생성물 1

HCID 690367913-(Dimethylamino)-1-(3-(trifluoromethyl)phenyl)propan-1-one hydrochloride수율 74.8%

시약·촉매·용매 1

HCID 702Ethanol
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실험 절차

A mixture of 1-(3-(trifluoromethyl)phenyl)ethanone (25.0 g) (II), dimethylamine hydrochloride (13.0 g), paraformaldehyde (4.8 g), 31% w/w aqueous hydrochloric acid (0.5 mL) in ethanol (70 mL) was stirred at reflux temperature for 24 hrs, then cooled down and the solvent flushed with toluene (50 mL). The precipitated pale yellow solid was then filtrated, washed with toluene and dried to give the title compound (IV) (28.0 g).

후처리

  1. temperatureat reflux temperature for 24 hrs
  2. temperaturecooled down
  3. customthe solvent flushed with toluene (50 mL)
  4. filtrationThe precipitated pale yellow solid was then filtrated
  5. washwashed with toluene
  6. customdried

출처 및 근거

ORD 기록
ord-6bd2898f1ddd46e486149b630ed4be59
출처 데이터셋
uspto-grants-2013_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08614353B2

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