Potassium Carbonate → 6-Bromo-2-pyrrolidin-1-ylmethyl-quinoline

HRID 1916628

반응식

HRID 1916628 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12]Br)[CH:6]=[CH:5]2.[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH:6]=[CH:5]2

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 589705326-Bromo-2-(bromomethyl)quinoline

생성물 1

HCID 673647966-Bromo-2-pyrrolidin-1-ylmethyl-quinoline

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

4.60 g (15.28 mmol) 6-bromo-2-bromomethyl-quinoline are added to a solution of 1.40 mL (16.8 mmol) pyrrolidine and 6.34 g (45.9 mmol) K2CO3 in 50 mL acetonitrile. The reaction is stirred overnight at RT and then the inorganic salts are filtered off. The organic phase is washed with water and the aqueous phase is extracted with EtOAc. The combined organic extracts are dried over MgSO4 and the solvent is eliminated i.vac.

후처리

  1. filtrationthe inorganic salts are filtered off
  2. washThe organic phase is washed with water
  3. extractionthe aqueous phase is extracted with EtOAc
  4. dry with materialThe combined organic extracts are dried over MgSO4

출처 및 근거

ORD 기록
ord-e81953fcf971414f8406f0421b472477
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

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