L-Malic Acid → Sunitinib Malate

HRID 1918241

반응식

HRID 1918241 반응식
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[C@H:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32]>N1C=CC=CC=1>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]

참가 물질

4

반응물 2

HCID 222656L-Malic AcidHCID 5329102Sunitinib

생성물 1

HCID 6456015Sunitinib Malate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Sunitinib base (600 mg) was dissolved in pyridine (5 ml) at 100° C. and L-malic acid (230 mg) was added to the hot solution. Slight heating provided clear solution. Sunitinib malate was formed overnight at 20° C.

후처리

  1. temperatureSlight heating
  2. customprovided clear solution

출처 및 근거

ORD 기록
ord-d5e4d1852a6b449f8fd5222a74ae2d90
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618309B2

연결된 노트

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