L-Malic Acid → Sunitinib Malate

HRID 1918242

반응식

HRID 1918242 반응식
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[C@H:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32]>C(OCCCC)(=O)C>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]

참가 물질

4

반응물 2

HCID 222656L-Malic AcidHCID 5329102Sunitinib

생성물 1

HCID 6456015Sunitinib Malate

시약·촉매·용매 1

HCID 31272Butyl Acetate용매

실험 절차

Sunitinib base (300 mg), L-malic acid (101 mg) and butyl acetate (10 ml) were heated to reflux 10 min. The suspension was allowed to cool to RT, filtered, washed with n-hexane and dried on air.

후처리

  1. temperatureto reflux 10 min
  2. filtrationfiltered
  3. washwashed with n-hexane
  4. customdried on air

출처 및 근거

ORD 기록
ord-140a84110053429bad95108b962e12b4
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618309B2

연결된 노트

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