Hydrochloric Acid → 2-Nitro-4-pyrrolidin-1-ylmethyl-benzoic acid

HRID 1921087노트

반응식

HRID 1921087 반응식
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:6][C:5]=1[N+:16]([O-:18])=[O:17].[OH-].[Na+].Cl.[Cl-].[Na+]>CO>[N+:16]([C:5]1[CH:6]=[C:7]([CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:8]=[CH:9][C:4]=1[C:3]([OH:19])=[O:2])([O-:18])=[O:17]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 574473262-Nitro-4-pyrrolidin-1-ylmethyl-benzoic acid methyl ester

생성물 1

HCID 574473272-Nitro-4-pyrrolidin-1-ylmethyl-benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-nitro-4-pyrrolidin-1-ylmethyl-benzoic acid methyl ester (1.1 g, 4.16 mmol) in methanol (35 mL) and 2N sodium hydroxide (4.16 mL, 8.32 mmol, 2 eq.) was stirred at room temperature for 7 hours, then neutralized with 2N hydrochloric acid (4.16 mL, 8.32 mmol) and evaporated to dryness affording a mixture of the title compound and sodium chloride that was used as such for the next step.

후처리

  1. customevaporated to dryness
  2. customaffording

출처 및 근거

ORD 기록
ord-17a3e19c250544ac9625d4242be2d95e
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173659B2

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