Chloroform → HCID 46235731, 화합물

HRID 1925184노트

반응식

HRID 1925184 반응식
C(Cl)(Cl)Cl.[SH:5][C:6]1[C:7]([NH:16][C:17]([C:19]2([CH2:25][CH:26]([CH2:29][CH3:30])[CH2:27][CH3:28])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:18])=[CH:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2.[C:31](Cl)(=[O:35])[CH:32]([CH3:34])[CH3:33]>N1C=CC=CC=1>[CH2:27]([CH:26]([CH2:29][CH3:30])[CH2:25][C:19]1([C:17]([NH:16][C:7]2[C:6]([S:5][C:31](=[O:35])[CH:32]([CH3:34])[CH3:33])=[CH:15][C:14]3[C:9]([CH:8]=2)=[CH:10][CH:11]=[CH:12][CH:13]=3)=[O:18])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1)[CH3:28]

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 62325Isobutyryl chlorideHCID 67427009HCID 67427009, 화합물

생성물 1

HCID 46235731HCID 46235731, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a chloroform solution of the product obtained in step B) are added 1.05 mol equivalents of isobutyryl chloride and 2.5 mol equivalents of pyridine at room temperature. The mixture is stirred for 1 hour, concentrated and then n-hexane is added. The solids are filtered off and the filtrate is concentrated. The remaining residue is purified by silica gel column chromatography to obtain the desired title compound.

후처리

  1. concentrationconcentrated
  2. additionn-hexane is added
  3. filtrationThe solids are filtered off
  4. concentrationthe filtrate is concentrated
  5. customThe remaining residue is purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-3a4df17bdfa34ba6843680b713f5177e
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178583B2

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