Hydrochloric Acid → 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid

HRID 1925576

반응식

HRID 1925576 반응식
[OH-].[Li+].C[O:4][C:5]([C:7]1[C:8]2[CH:16]=[CH:15][NH:14][C:9]=2[N:10]=[C:11]([Cl:13])[CH:12]=1)=[O:6].Cl>CO>[Cl:13][C:11]1[CH:12]=[C:7]([C:5]([OH:6])=[O:4])[C:8]2[CH:16]=[CH:15][NH:14][C:9]=2[N:10]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 53413062Methyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate

생성물 1

HCID 533995756-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid수율 96.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a 100 ml round-bottomed flask, 7.5 ml of a 1M aqueous solution of lithium hydroxide are added, at ambient temperature, to a suspension of 527 mg of 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid methyl ester obtained according to the preceding stage, in 15 ml of methanol. After stirring for 2.5 hours at ambient temperature, 7.5 ml of 1N hydrochloric acid are added dropwise. After stirring for ½ hour, the solid is filtered off, washed with 25 ml of water and dried. 475 mg of 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid are obtained in the form of a beige solid, the characteristics of which are the following:

후처리

  1. customobtained
  2. stirringAfter stirring for ½ hour
  3. filtrationthe solid is filtered off
  4. washwashed with 25 ml of water
  5. customdried

출처 및 근거

ORD 기록
ord-30b8c646190946a79f1b611048175ec7
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178687B2

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