Dichloromethane → bis(4-oxo-2-phenyl-4H-chromen-3-yl)terephthalate

HRID 1925668

반응식

HRID 1925668 반응식
[OH:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:19](Cl)(=[O:29])[C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1.ClCCl.C(N([CH2:39][CH3:40])CC)C>O>[O:12]=[C:11]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[O:4][C:3]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[C:2]1[O:1][C:19](=[O:29])[C:20]1[CH:28]=[CH:27][C:23]([C:24]([O:1][C:2]2[C:11](=[O:12])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[O:4][C:3]=2[C:40]2[CH:39]=[CH:18][CH:13]=[CH:14][CH:15]=2)=[O:25])=[CH:22][CH:21]=1

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 7488Terephthaloyl chlorideHCID 8471TriethylamineHCID 11349Flavonol

생성물 1

HCID 57983717bis(4-oxo-2-phenyl-4H-chromen-3-yl)terephthalate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To the three-necked round bottom flask attached with reflux condenser, calcium chloride guard tube and nitrogen inlet, 3-hydroxy-2-phenyl-4H-chromen-4-one (0.59 g), terephthaloyl chloride (0.59 g) and dichloromethane (50 ml) were charged. Then triethyl amine (0.29 g) was charged and the reaction mixture was stirred at room temperature and monitored by thin layer chromatography (TLC). On completion of the reaction 10 ml water was added to the reaction mixture and the organic layer was separated. The organic layer was dried and evaporated under reduced pressure to give the product.

후처리

  1. temperaturewith reflux condenser, calcium chloride guard tube and nitrogen inlet
  2. additionwas added to the reaction mixture
  3. customthe organic layer was separated
  4. customThe organic layer was dried
  5. customevaporated under reduced pressure
  6. customto give the product

출처 및 근거

ORD 기록
ord-05698b17433241a3bb7f354098e0d834
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178702B2

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