Water → HCID 57964979, 화합물

HRID 1931579노트

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HRID 1931579 반응식
[CH:1]([C:4]1[N:8]=[C:7]([CH:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2)[O:6][N:5]=1)([CH3:3])[CH3:2].O.[NH2:17][NH2:18].[BH4-].[Na+].O>CO>[CH:1]([C:4]1[N:8]=[C:7]([CH:9]2[CH2:14][CH2:13][CH:12]([NH:17][NH2:18])[CH2:11][CH2:10]2)[O:6][N:5]=1)([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 4311764Sodium borohydrideHCID 579649554-(3-Isopropyl-1,2,4-oxadiazol-5-YL)cyclohexan-1-one2회

생성물 1

HCID 57964979HCID 57964979, 화합물수율 43%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
0 °C

실험 절차

A mixture of 4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-cyclohexanone (Intermediate 11; 600 mg, 2.9 mmol) and hydrazine hydrate (160 mg, 3.2 mmol) in methanol (2 mL) was heated at reflux for 3 h. The reaction mixture was cooled to 0° C. and sodium borohydride (220 mg, 5.8 mmol) was added portionwise. The reaction mixture was stirred at 0° C. for 4 h and then at room temperature overnight. Water was added and the aqueous layer was extracted three times with ethyl acetate. The combined organic layers were dried (sodium sulfate), filtered, and evaporated to give [4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-cyclohexyl]-hydrazine (280 mg, 43%) which was used directly in the next step without further purification. Mass spectrum M+=224.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 3 h
  3. customat room temperature
  4. customovernight
  5. extractionthe aqueous layer was extracted three times with ethyl acetate
  6. dry with materialThe combined organic layers were dried (sodium sulfate)
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-d534982253bc416bbdbdea12a5bd85f7
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188098B2

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