Hydrochloric Acid → 4-[2-(3,5-Dichloro-4-pyridyl)-1-oxoethyl]-7-methoxybenzofuran-2-carboxylic acid

HRID 1937423노트

반응식

HRID 1937423 반응식
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:27])[C:7]=1[CH2:8][C:9]([C:11]1[C:16]2[CH:17]=[C:18]([C:20]([O:22]CC)=[O:21])[O:19][C:15]=2[C:14]([O:25][CH3:26])=[CH:13][CH:12]=1)=[O:10].[OH-].[Na+].Cl>CO>[Cl:27][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[CH2:8][C:9]([C:11]1[C:16]2[CH:17]=[C:18]([C:20]([OH:22])=[O:21])[O:19][C:15]=2[C:14]([O:25][CH3:26])=[CH:13][CH:12]=1)=[O:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22733875Ethyl 4-[2-(3,5-dichloro-4-pyridyl)-1-oxoethyl]-7-methoxybenzofuran-2-carboxylate

생성물 1

HCID 227341684-[2-(3,5-Dichloro-4-pyridyl)-1-oxoethyl]-7-methoxybenzofuran-2-carboxylic acid수율 96.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Ethyl 4-[2-(3,5-dichloro-4-pyridyl)-1-oxoethyl]-7-methoxybenzofuran-2-carboxylate (6.0 g) was dissolved in methanol (60 ml), 5 N aqueous NaOH (15 ml) was added thereto under cooling on ice, and the mixture was returned to room temperature and stirred for 1 hour. Under cooling on ice, the reaction mixture was acidified by dropwise adding 1 N aqueous HCl, and the precipitated crystals were collected by filtration and washed with water to give the desired compound (5.4 g, 96%) as colorless crystals.

후처리

  1. temperatureunder cooling on ice
  2. customwas returned to room temperature
  3. temperatureUnder cooling on ice
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed with water

출처 및 근거

ORD 기록
ord-b54a1c71068a479791f8647616bab739
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06395738B1

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