Ethylenediamine → HCID 86751684, 화합물

HRID 1938151노트

반응식

HRID 1938151 반응식
[CH:1]([N:4]([CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][CH3:31])[CH2:5][C:6]#[C:7][CH2:8][NH:9][C:10]([C:12]12[CH2:21][CH:16]3[CH2:17][CH:18]([CH2:20][CH:14]([CH2:15]3)[CH2:13]1)[CH2:19]2)=[O:11])([CH3:3])[CH3:2].C(N)CN.[BH4-].[Na+]>C(O)C.O.O.O.O.O.O.[Ni](Cl)Cl>[CH:1]([N:4]([CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[O:30][CH3:31])[CH2:5][CH:6]=[CH:7][CH2:8][NH:9][C:10]([C:12]12[CH2:21][CH:16]3[CH2:15][CH:14]([CH2:20][CH:18]([CH2:17]3)[CH2:19]1)[CH2:13]2)=[O:11])([CH3:3])[CH3:2]

참가 물질

6

반응물 3

HCID 3301EthylenediamineHCID 4311764Sodium borohydrideHCID 86751685HCID 86751685, 화합물

생성물 1

HCID 86751684HCID 86751684, 화합물수율 79.6%

시약·촉매·용매 2

HCID 11791229Dichloronickel;hexahydrate촉매HCID 702Ethanol용매

실험 절차

A mixture of adamantane-1-carboxylic acid (4-{isopropyl-[2-(2-methoxyphenyl)ethyl]amino}but-2-ynyl)amide, (90 mg, 0.21 mmol), nickel chloride hexahydrate (60 mg, 0.25 mmol), ethylenediamine (0.15 ml, 0.25 mmol) and sodium borohydride (0.25 ml 1N solution in EtOH, 0.25 mmol) in 5 ml ethanol was stirred at ambient temperature for 10 h. The mixture was filtered, the solvent removed and the residue taken up in methylene chloride and washed with water. Evaporation of the solvent gave 71 mg of an oil.

후처리

  1. filtrationThe mixture was filtered
  2. customthe solvent removed
  3. washwashed with water
  4. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-cb410290233e46ce8da19ce652fc8d0d
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693630

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