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Hydrochloric Acid → 6-[5-Ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoic acid

HRID 1938509
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HRID 1938509 반응식
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([C:21]2[NH:22][C:23](=[O:30])[C:24]([CH:27]([CH3:29])[CH3:28])([CH3:26])[N:25]=2)=[C:7]([CH:20]=1)[C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]C)=[O:17])=[O:9])[CH3:2].[OH-].[Na+].Cl>O1CCCC1>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([C:21]2[NH:22][C:23](=[O:30])[C:24]([CH:27]([CH3:29])[CH3:28])([CH3:26])[N:25]=2)=[C:7]([CH:20]=1)[C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:9])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22450188Methyl 6-[5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoate

생성물 1

HCID 189772396-[5-Ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A stirred solution of methyl 6-[5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoate (5.14 g, 12.35 mmol) in tetrahydrofuran is treated with 2N sodium hydroxide (15 mL). The resulting mixture is stirred at room temperature for 24 hours. After this period, the reaction mixture is concentrated in vacuo to obtain a residue. The residue is cooled with an ice bath and acidified with concentrated hydrochloric acid. The resulting precipitate is isolated by vacuum filtration and washed with water to give the title product as a white solid, mp 76°-81° C.

후처리

  1. waitAfter this period
  2. concentrationthe reaction mixture is concentrated in vacuo
  3. customto obtain a residue
  4. temperatureThe residue is cooled with an ice bath
  5. customThe resulting precipitate is isolated by vacuum filtration
  6. washwashed with water

출처 및 근거

ORD 기록
ord-ef7db4d8cd6c4e9fae62a074908f2af0
출처 데이터셋
uspto-grants-1997_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05693658

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