Glycine → HCID 178446845, 화합물

HRID 1939643

반응식

HRID 1939643 반응식
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[OH-].[Na+].[C:8](=[NH:15])(OC)[CH2:9][CH2:10][CH2:11][CH3:12]>CO.O.C1(C)C=CC=CC=1>[C:8]([NH:1][CH2:2][C:3]([OH:5])=[O:4])(=[NH:15])[CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

7

반응물 3

HCID 750GlycineHCID 14798Sodium HydroxideHCID 5743466Methyl pentanimidate

생성물 1

HCID 178446845HCID 178446845, 화합물

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 1140Toluene용매

반응 조건

온도
0 °C

실험 절차

A stirred suspension of glycine (18.77 g, 0.25 mol) in methanol (80 ml) and water (4.5 ml) was cooled to 0° C. and adjusted to pH 9.6 by adding 30 percent strength sodium hydroxide solution. Methyl pentanimidate (68.81 g of a 42 percent strength solution in toluene=0.25 mol) was added to this suspension over the course of 5 minutes. After stirring for 18 hours at room temperature, the suspension was filtered, and the filter cake was washed with toluene (75 ml) and dried. The yield of the title compound was 25.45 g (purity>95 percent by H-NMR), 64 percent based on glycine. Other data concerning the title compound was:

후처리

  1. filtrationthe suspension was filtered
  2. washthe filter cake was washed with toluene (75 ml)
  3. customdried

출처 및 근거

ORD 기록
ord-29a4371eaa2e4314b849bb321c42dbc2
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05696272

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