Acetic Acid → HCID 86651312, 화합물

HRID 1942389

반응식

HRID 1942389 반응식
C([O:3][CH:4](OCC)[CH2:5][CH2:6][CH2:7][NH:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:13][CH2:12]1)=[O:10])C.C(O)(=O)C.Cl>C(O)C>[O:3]=[CH:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([N:11]1[CH2:12][CH2:13][CH:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:15][CH2:16]1)=[O:10]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 66937642N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide

생성물 1

HCID 86651312HCID 86651312, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.39 g (4 mmol) N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide, 5 mL acetic acid, 2.5 mL 1N aqueous hydrochloric acid and 20 mL ethanol are put together and stirred for 16 hours under argon atmosphere. Ethanol is evaporated. Then the resulting residue is dispersed in dichloromethane and extracted with saturated sodium bicarbonate solution. The organic phase is dried with sodium sulfate and the solvent evaporated in vacuum. The crude product is obtained in almost quantitative yield.

후처리

  1. customEthanol is evaporated
  2. additionThen the resulting residue is dispersed in dichloromethane
  3. extractionextracted with saturated sodium bicarbonate solution
  4. dry with materialThe organic phase is dried with sodium sulfate
  5. customthe solvent evaporated in vacuum

출처 및 근거

ORD 기록
ord-d24f9ad5c7b0436da7518018cb1282b0
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389555B2

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