반응식
[C:1]([C:5]1[CH:15]=[CH:14][C:8]([O:9][CH2:10][C:11]([OH:13])=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].NC1C=[C:19](C=CN=1)[C:20](N)=[O:21].CC[N:28]([CH:32]([CH3:34])C)[CH:29]([CH3:31])C.C1C[N:38]([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.CN([CH:71]=[O:72])C>>[CH3:71][O:72][C:20](=[O:21])[C:19]1[CH:31]=[CH:29][N:28]=[C:32]([NH:38][C:11](=[O:13])[CH2:10][O:9][C:8]2[CH:7]=[CH:6][C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])=[CH:15][CH:14]=2)[CH:34]=1참가 물질
6
실험 절차
A solution of (4-tert-butyl-phenoxy)acetic acid (200.1 mg, 0.96 mmol), 2-amino-isonicotinamide (109.5 mg, 0.72 mmol), DIPEA (0.17 ml, 0.96 mmol) and PyBOP (499.5 mg, 0.96 mmol) in DMF 6.0 mL was stirred, then partitioned between ethyl acetate and water. The organic phase was purified by preparative TLC(Hexane:EtoAC:MeOH=15:3:1) to give 2-[2-(4-tert-butyl-phenoxy)-acetylamino]-isonicotinic acid methyl ester as a white solid (124.0 mg, 50.3% yield).
후처리
- custompartitioned between ethyl acetate and water
- customThe organic phase was purified by preparative TLC(Hexane:EtoAC:MeOH=15:3:1)
출처 및 근거
- ORD 기록
- ord-36b99e1d20c54840a42e6cbee3b2a6b5
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08394799B2
연결된 노트
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