Hydrochloric Acid → HCID 89077752, 화합물

HRID 1946212노트

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HRID 1946212 반응식
[CH3:1][C:2]1([CH3:28])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([O-:13])=O)[CH:9]=2)[N+:4]2[CH:14]=[CH:15][C:16]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH3:27])[CH:19]=3)=[CH:17][C:3]1=2.[ClH:29].[C:30]([N:37]1[CH:41]=[CH:40]N=[CH:38]1)(N1C=CN=C1)=O.Cl.Cl.[NH2:44][CH2:45][CH2:46][S:47][S:48][CH2:49][CH2:50][NH2:51]>CN1CCCC1=O.O1CCOCC1.C(OCC)C.C(N(C(C)C)CC)(C)C.CC(C)=O>[Cl-:29].[Cl-:29].[S:47]([CH2:46][CH2:45][NH:44][C:11]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N+:4]1[CH:14]=[CH:15][C:16]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH3:27])[CH:19]=3)=[CH:17][C:3]=1[C:2]2([CH3:1])[CH3:28])=[O:13])[S:48][CH2:49][CH2:50][NH:51][C:11]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N+:4]1[CH:14]=[CH:15][C:16]([C:40]3[C:25]4[C:38](=[CH:23][CH:22]=[CH:21][CH:26]=4)[N:37]([CH3:30])[CH:41]=3)=[CH:17][C:3]=1[C:2]2([CH3:28])[CH3:1])=[O:13]

참가 물질

10

반응물 4

HCID 313Hydrochloric AcidHCID 5941Cystamine DihydrochlorideHCID 682631,1'-CarbonyldiimidazoleHCID 68743932HCID 68743932, 화합물

생성물 1

HCID 89077752HCID 89077752, 화합물

시약·촉매·용매 5

HCID 180Acetone용매HCID 3283Diethyl Ether용매HCID 13387N-methyl-2-pyrrolidone용매HCID 312751,4-Dioxane용매HCID 81531Diisopropylethylamine용매

실험 절차

10,10-dimethyl-8-(1-methyl-1H-indol-3-yl)-10H-pyrido-[1,2-a]indolium-2-carboxylate 0.37 g was solubilized in 5 mL N-methylpyrrolidinone (NMP), a solution of HCl in dry dioxane and diethyl ether (1 mL; 1N; 1:3) was added and 1,1′-carbonyldiimidazole (320 mg) was progressively added. After 3 h, 200 mg of cystamine dihyrochloride in mL diisopropylethylamine (DIPEA) were added to the mixture. After 24 h, the reaction mixture was poured in 100 mL acetone. The resulting solid was filtered, washed with acetone and dried under vacuum (340 mg, yellow powder). Analyses were in accordance with the expected structure.

후처리

  1. waitAfter 24 h
  2. filtrationThe resulting solid was filtered
  3. washwashed with acetone
  4. customdried under vacuum (340 mg, yellow powder)

출처 및 근거

ORD 기록
ord-38778b693abf47bc90b7d54082ae4183
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08398722B2

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