Isobutylamine → N-(2-methylpropyl)cyclopentanamine

HRID 1946685

반응식

HRID 1946685 반응식
[C:1]1(=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:7]([NH2:11])[CH:8]([CH3:10])[CH3:9].[BH4-].[Na+]>C(O)C>[CH:1]1([NH:11][CH2:7][CH:8]([CH3:10])[CH3:9])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 6558IsobutylamineHCID 8452CyclopentanoneHCID 4311764Sodium borohydride

생성물 1

HCID 28428761N-(2-methylpropyl)cyclopentanamine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A mixture of cyclopentanone (10 g, 0.12 mol) and isobutyl amine (29.5 ml, 0.297 mol) was heated at 70° C. for 3 h under nitrogen. After cooling to 0° C., absolute ethanol (50 ml) was added to the reaction mixture, followed by sodium borohydride (6.59 g, 0.178 mol) in portions. The reaction mixture stirred at RT for 12 h, the solvent was removed under vacuum. The residue was taken up in MTBE and washed with water and brine. The organic layer was dried over Na2SO4, evaporated to dryness and the crude was purified by chromatography using silica gel (60-120 mesh), dichloromethane\methanol as eluent to afford of the titled compound as a yellow liquid.

후처리

  1. temperatureAfter cooling to 0° C.
  2. customthe solvent was removed under vacuum
  3. washwashed with water and brine
  4. dry with materialThe organic layer was dried over Na2SO4
  5. customevaporated to dryness
  6. customthe crude was purified by chromatography

출처 및 근거

ORD 기록
ord-0e81c911447b48efbf21dfe4b58644d4
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399448B2

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