1,4-Dibromobutane → Diethyl (4-bromobutyl)phosphonate

반응식

[Br:1][CH2:2][CH2:3][CH2:4][CH2:5]Br.[CH2:7]([O:9][P:10]([O:14]CC)[O:11][CH2:12][CH3:13])[CH3:8]>>[CH2:7]([O:9][P:10]([CH2:5][CH2:4][CH2:3][CH2:2][Br:1])(=[O:14])[O:11][CH2:12][CH3:13])[CH3:8]

참가 물질

반응물 2

HCID 80561,4-Dibromobutane

HCID 31215Triethyl phosphite

생성물 1

HCID 14411016Diethyl (4-bromobutyl)phosphonate

실험 절차

In another method, 1,4-dibromobutane is heated with triethylphosphite to give diethyl-4-bromobutylphosphonate, for example, as described by Eberhard and Westheimer, 1965. The resultant bromide is then reacted with, for example, biphenyl-4-carboxylic acid in dimethylformamide, in the presence of potassium carbonate. Again, the phosphate ester groups, e.g., ethyl groups, are removed e.g., with trimethylsilylbromide or left in place. An example of such a method is illustrated in the following scheme.

출처 및 근거

ORD 기록: ord-14474d8dccbd4aedb2d643abfe03b0d5
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07745424B2

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