Hydrochloric Acid → 3-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid

HRID 1951225노트

반응식

HRID 1951225 반응식
C[O:2][C:3](=[O:20])[CH:4](C(OCC)=O)[CH2:5][C:6]1[S:7][C:8]([NH:11][C:12]([NH2:14])=[S:13])=[N:9][N:10]=1.Cl>[OH-].[Na+]>[NH:11]([C:8]1[S:7][C:6]([CH2:5][CH2:4][C:3]([OH:20])=[O:2])=[N:10][N:9]=1)[C:12]([NH2:14])=[S:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86653060Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester

생성물 1

HCID 866062213-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester (0.675 g, 2.91 mmol) is suspended in 2M NaOH (8 ml) and the reaction is stirred at reflux for 3.5 hours. When cool, the solution is acidified to pH 3 with 6M HCl and the titled compound is removed by filtration and dried.

후처리

  1. temperatureat reflux for 3.5 hours
  2. temperatureWhen cool
  3. customthe titled compound is removed by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-e963e179c2b34315ad0c3f3def9be1e2
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404684B2

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